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Splanchnic Tissue Oxygenation for Predicting Feeding Tolerance in Preterm Infants
Carlo Dani1, Iuri Corsini2, Marta Generoso2
1Department of Neurosciences, Psychology, Drug Research and Children's Health, University of Florence, Italy cdani@unifi.it.
JPEN. Journal of Parenteral and Enteral Nutrition
|June 18, 2014
Summary
Splanchnic oxygenation and extraction in preterm infants do not predict feeding intolerance. Birth weight under 1000g and PDA increase feeding intolerance risk.
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Biomedical Engineering
Background:
- Feeding intolerance is common in preterm infants, necessitating early biomarkers for effective feeding strategies.
- Near-infrared spectroscopy (NIRS) offers non-invasive monitoring of splanchnic oxygenation.
Purpose of the Study:
- To assess if splanchnic regional oxygenation (rSO2S) and fractional oxygen extraction ratio (FOES) predict time to full enteral feeding.
- To determine if rSO2S and FOES can predict feeding intolerance in preterm infants.
Main Methods:
- rSO2S and FOES were measured in preterm infants (25-31 weeks gestational age) within 24-72 hours of life.
- Measurements were taken during continuous enteral feeding.
Main Results:
- No correlation was found between rSO2S, FOES, and the time to achieve full enteral feeding.
- Low birth weight (<1000g) and patent ductus arteriosus (PDA) were significant risk factors for feeding intolerance.
Conclusions:
- Early splanchnic oxygenation and extraction are not reliable predictors of feeding progression in preterm infants.
- Birth weight and PDA are key factors influencing feeding intolerance in this population.
