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Nanoparticle ζ-potential measurements using tunable resistive pulse sensing with variable pressure.

James A Eldridge1, Geoff R Willmott2, Will Anderson3

  • 1Callaghan Innovation, 69 Gracefield Road, PO Box 31310, Lower Hutt 5040, New Zealand; The MacDiarmid Institute for Advanced Materials and Nanotechnology, School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6140, New Zealand; School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington 6140, New Zealand.

Journal of Colloid and Interface Science
|June 18, 2014
PubMed
Summary

Tunable resistive pulse sensing (TRPS) offers reproducible nanoparticle zeta-potential measurements, outperforming traditional methods. Duration analysis via TRPS provides more reliable data than rate analysis, with variations under ±5 mV.

Keywords:
Resistive pulse sensingTunable poreZeta-potential

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Area of Science:

  • Nanotechnology
  • Surface Chemistry
  • Physical Chemistry

Background:

  • Resistive pulse sensing (RPS) measures nanoparticle electrophoretic mobility and zeta-potential.
  • Unlike light scattering, RPS provides single-particle data.
  • Tunable resistive pulse sensing (TRPS) enhances RPS capabilities.

Purpose of the Study:

  • To compare different TRPS analysis methods for zeta-potential measurement.
  • To evaluate the impact of surface charge density on zeta-potential.
  • To investigate electrokinetic and pressure-driven transport interactions.

Main Methods:

  • Utilized tunable resistive pulse sensing (TRPS) on carboxylated polystyrene nanoparticles (160-230 nm).
  • Applied varying pressure (±500 Pa) across a tunable pore.
  • Analyzed resistive pulse rate and full-width half maximum duration for zeta-potential calculations.

Main Results:

  • Duration analysis yielded more reproducible zeta-potential data (<±5 mV variation) than rate analysis.
  • A monotonic relationship between zeta-potential and surface charge density was observed for values greater than -0.32 C m⁻².
  • Complex pulse data near zero net particle flux were analyzed by considering competing transport mechanisms.
  • TRPS and phase analysis light scattering showed a typical difference of 15% (<5 mV).

Conclusions:

  • TRPS duration analysis is a robust method for accurate zeta-potential determination.
  • TRPS provides valuable insights into nanoparticle surface charge and transport phenomena.
  • TRPS offers a comparable alternative to light scattering techniques for zeta-potential measurements.