Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Computed Tomography01:10

Computed Tomography

7.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
7.6K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Spatial resolution of the metastatic osteosarcoma tumor microenvironment using immunolabeling across murine, canine and human lung.

Journal of translational medicine·2026
Same author

Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

Comprehensive analysis of non-tumor lung, liver, and kidney transcriptomes in canine metastatic osteosarcoma.

Communications biology·2026
Same author

Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma.

Frontiers in immunology·2025
Same author

Biodistribution-Driven Discovery Identifies a Glycosidase-Cleavable Linker to Reprogram Radiotheranostics.

bioRxiv : the preprint server for biology·2025
Same author

Spatial Transcriptomics Advances the Use of Canine Patients in Cancer Research: Analysis of Osteosarcoma-Bearing Pet Dogs Enrolled in a Clinical Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025

Related Experiment Video

Updated: Apr 28, 2026

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
08:55

Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

Published on: November 2, 2014

13.8K

Cancer and comparative imaging.

Amy K LeBlanc

    ILAR Journal
    |June 18, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Comparative oncology leverages pet dogs with cancer to accelerate anticancer drug development. Integrating molecular imaging enhances this approach, improving drug and imaging agent discovery for both animals and humans.

    Keywords:
    cancercomparative oncologymolecular imaging

    More Related Videos

    Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
    09:18

    Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

    Published on: February 3, 2026

    1.0K
    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
    10:25

    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

    Published on: April 12, 2024

    2.3K

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
    08:55

    Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence

    Published on: November 2, 2014

    13.8K
    Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
    09:18

    Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

    Published on: February 3, 2026

    1.0K
    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
    10:25

    Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning

    Published on: April 12, 2024

    2.3K

    Area of Science:

    • Comparative oncology
    • Translational cancer research
    • Drug discovery and development

    Background:

    • Comparative oncology utilizes pet dogs with naturally occurring cancers as a complementary model to traditional animal models.
    • This approach aids in evaluating new anticancer drugs, refining doses, and validating drug targets in vivo.
    • Existing comparative oncology studies primarily focus on drug efficacy, with less emphasis on imaging techniques.

    Purpose of the Study:

    • To propose the expansion of comparative cancer imaging within drug discovery and development.
    • To highlight the value of molecular imaging in comparative oncology studies.
    • To demonstrate the utility of spontaneous canine cancers as a research tool for imaging agent development.

    Main Methods:

    • Review of existing comparative oncology studies incorporating molecular imaging techniques.
    • Analysis of diagnostic and molecular imaging's role in cancer management.
    • Focus on spontaneous canine cancers as models for human diseases.

    Main Results:

    • Comparative oncology studies using pet dogs have successfully modeled drug pharmacokinetics, pharmacodynamics, and target validation.
    • Molecular imaging techniques provide individualized data for patient selection and therapy response assessment.
    • Spontaneous canine cancers are valuable models for developing novel imaging agents.

    Conclusions:

    • Integrating molecular imaging into comparative oncology significantly enhances drug discovery and development pipelines.
    • Canine cancer models offer a unique platform for validating imaging agents and therapeutic strategies.
    • This approach holds promise for advancing cancer treatment in both veterinary and human medicine.