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Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
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Adrenergic Receptors: ɑ Subtype01:31

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Hormones of the Adrenal Glands01:31

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Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
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Adrenergic Receptors: β Subtype01:26

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β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
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Adrenergic Receptors (Adrenoceptors): Classification01:27

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Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Adrenomedullin and diabetes.

Hoi Kin Wong1, Fai Tang1, Tsang Tommy Cheung1

  • 1Hoi Kin Wong, Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong, China.

World Journal of Diabetes
|June 18, 2014
PubMed
Summary

Adrenomedullin (ADM), a peptide hormone, is elevated in diabetes and linked to complications. Lowering ADM levels may help manage diabetic issues and reduce associated health problems.

Keywords:
AdrenomedullinDiabetesDiabetic complicationsHyperglycemiaTherapeutics

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Area of Science:

  • Endocrinology
  • Vascular Biology
  • Metabolic Diseases

Background:

  • Adrenomedullin (ADM) is a peptide hormone with diverse physiological roles, including hormonal secretion, glucose metabolism, and inflammation.
  • ADM is primarily expressed in the vasculature and influences blood pressure regulation.
  • ADM plays a role in insulin balance, suggesting a connection to diabetes development.

Purpose of the Study:

  • To investigate the association between Adrenomedullin (ADM) levels and diabetes.
  • To explore the relationship between ADM and diabetic complications.
  • To understand the potential mechanisms linking ADM to diabetes.

Main Methods:

  • This study is a review of existing literature on Adrenomedullin (ADM) and diabetes.
  • Analysis of plasma ADM levels in diabetic and non-diabetic individuals.
  • Correlation of ADM levels with the presence and severity of diabetic complications.

Main Results:

  • Plasma ADM levels are significantly higher in individuals with diabetes compared to healthy controls.
  • Elevated ADM levels are further increased in patients experiencing diabetic complications.
  • ADM levels correlate with specific complications like renal failure and retinopathy in type 1 diabetes, and a broader range in type 2 diabetes.

Conclusions:

  • Increased Adrenomedullin (ADM) is strongly associated with diabetes and its complications.
  • Potential contributing factors to elevated ADM in diabetes include hyperinsulinemia, oxidative stress, and endothelial injury.
  • Reducing ADM levels presents a potential therapeutic strategy for mitigating diabetic complications.