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Related Concept Videos

Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
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Cell-type-specific, Aptamer-functionalized Agents for Targeted Disease Therapy.

Jiehua Zhou1, John J Rossi2

  • 1Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA.

Molecular Therapy. Nucleic Acids
|June 18, 2014
PubMed
Summary
This summary is machine-generated.

Cell-specific aptamers offer a promising "magic bullet" approach for targeted therapy. These aptamers, developed using SELEX technology, enable precise delivery of therapeutic agents to diseased cells, enhancing treatment efficacy.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Delivery

Background:

  • The
  • magic bullet
  • concept aims for targeted cell killing in therapy.
  • Targeted therapy seeks to address molecular defects in diseases.
  • Efficient drug delivery remains a challenge in cancer and infectious disease treatment.

Purpose of the Study:

  • To review advances in cell-specific aptamers for targeted disease therapy.
  • To discuss aptamer conjugation strategies and associated challenges.

Main Methods:

  • SELEX (Systematic Evolution of Ligands by Exponential Enrichment) technology for aptamer development.
  • Covalent linking or physical functionalization of aptamers with therapeutic agents or nanocarriers.

Main Results:

  • Cell-specific aptamers have been successfully adapted for targeted drug delivery in vitro and in vivo models.
  • Aptamer conjugation enhances recognition of targeted cells/tissues and internalization of therapeutic compounds.
  • Numerous cell-type-specific aptamers are available for targeting various diseases.

Conclusions:

  • Cell-specific aptamers represent a significant advancement in targeted disease therapy.
  • Strategic conjugation of aptamers with therapeutics improves drug concentration and efficacy.
  • Further research into conjugation strategies and challenges is warranted for clinical translation.