Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

30.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.3K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

851
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
851
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.7K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.7K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

3.8K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.8K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

1.1K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.1K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.7K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observations of the Gas Phase Composition of the 2024 BioLab Industrial Plume in the Atlanta Metropolitan Area.

Environmental science & technology letters·2026
Same author

Fate of isoprene peroxy radical constrains the urban photochemical regime.

Science advances·2026
Same author

An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health.

Frontiers in neurology·2026
Same author

Preconception health as a target for improved pregnancy outcomes: Where do we go from here?

Pregnancy hypertension·2025
Same author

Characterizing individuals with elevated sweat chloride results in the absence of CFTR variants.

Orphanet journal of rare diseases·2025
Same author

Placental Growth Factor and Female Long-Term Hypertension.

Journal of clinical medicine·2025

Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.4K

A potential role for allostatic load in preeclampsia.

Vanessa J Hux1, James M Roberts

  • 1Vanderbilt University School of Medicine, Nashville, TN, USA, vanessa.hux@osumc.edu.

Maternal and Child Health Journal
|June 19, 2014
PubMed
Summary

Early pregnancy allostatic load (AL), a measure of physiologic risk and chronic stress, is linked to higher preeclampsia risk. Higher AL scores significantly increase the odds of developing preeclampsia.

Area of Science:

  • Reproductive Medicine
  • Cardiovascular Health
  • Stress Physiology

Background:

  • Preeclampsia is a serious pregnancy disorder with unknown causes, leading to maternal/fetal complications and future cardiovascular disease.
  • Existing risk factors like obesity are known, but early pregnancy markers for preeclampsia remain crucial for prediction.
  • Allostatic load (AL) quantifies cumulative physiologic wear and tear from chronic stress, offering a potential predictive measure.

Purpose of the Study:

  • To investigate the association between allostatic load (AL) measured early in pregnancy and the subsequent development of preeclampsia.
  • To determine if pregnancy-specific AL is a stronger predictor of preeclampsia than obesity.

Main Methods:

  • A case-control study matched 38 preeclamptic cases with 75 controls (<15 weeks gestation).

More Related Videos

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.0K
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

15.1K

Related Experiment Videos

Last Updated: Apr 28, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

1.4K
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
12:17

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

10.0K
Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

15.1K
  • Allostatic load (AL) was calculated using 9 cardiovascular, metabolic, and inflammatory markers.
  • Conditional logistic regression and Akaike Information Criterion (AIC) were used for statistical comparison.

    • Main Results:

    • Women who developed preeclampsia had significantly higher early pregnancy AL scores (1.25 ± 0.68 vs. 0.83 ± 0.62, p = 0.002).
    • Higher AL was associated with increased odds of preeclampsia (OR 2.91, 95% CI 1.50-5.65).
    • The AL model demonstrated a better fit for predicting preeclampsia compared to obesity (AIC difference >2).

    Conclusions:

    • Elevated allostatic load (AL) in early pregnancy is a significant predictor of increased preeclampsia risk.
    • AL may reflect the impact of maternal systemic function and chronic stress on preeclampsia development.
    • This study highlights AL as a promising early marker for identifying women at risk of preeclampsia.