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Related Concept Videos

Diversity of Antigen Receptors01:28

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Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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The genetics of immunity.

Brian P Lazzaro1, David S Schneider2

  • 1Department of Entomology, Cornell University, Ithaca, NY 14853 bplazzaro@cornell.edu.

G3 (Bethesda, Md.)
|June 19, 2014
PubMed
Summary

This commentary introduces the Genetics of Immunity collection, highlighting new research in the GSA journals. Explore the intricate relationship between genetics and immune system function in these inaugural articles.

Keywords:
complex geneticscomplex immunityinfectioninnate immunityresistancetolerance

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Area of Science:

  • Genetics
  • Immunology
  • Molecular Biology

Background:

  • Introduces a new joint collection on the Genetics of Immunity.
  • Features inaugural articles from GENETICS and G3: Genes|Genomes|Genetics.
  • Focuses on the intersection of genetic mechanisms and immune responses.

Discussion:

  • Examines the genetic underpinnings of immune system development and function.
  • Discusses how genetic variations influence susceptibility and resistance to diseases.
  • Highlights the importance of genetic research in understanding immunity.

Key Insights:

  • The Genetics of Immunity is a rapidly evolving field.
  • Genetic factors play a crucial role in shaping immune responses.
  • Interdisciplinary research is essential for advancing our understanding of immunity.

Outlook:

  • This ongoing collection will feature further research in the Genetics of Immunity.
  • Future studies will likely uncover novel genetic targets for immune-related therapies.
  • Advances in genetic technologies will accelerate discoveries in immunology.