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Novel microstructured sildenafil dosage forms as wound healing promoters
Wael M Samy1, Asser I Ghoneim, Nazik A Elgindy
1Alexandria University, Department of Industrial Pharmacy, Faculty of Pharmacy , Alexandria , Egypt +2 03 3630 815 ; +2 03 4873 273 ; wsamy73@yahoo.com , w.sami@bau.edu.lb.
Expert Opinion on Drug Delivery
|June 19, 2014
Summary
Biodegradable chitosan/sildenafil citrate (SC) powders and gels show significant wound healing benefits. These formulations accelerated wound area reduction and improved tensile strength in preclinical models.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Wound Healing Research
Background:
- Sildenafil citrate (SC) has potential therapeutic applications beyond its primary use.
- Biodegradable polymers offer versatile platforms for drug delivery and tissue regeneration.
Purpose of the Study:
- To investigate the efficacy of combining biodegradable polymers with sildenafil citrate (SC) for enhanced wound healing.
- To develop and characterize micronized powdered formulations of SC using chitosan and chitosan/gum Arabic.
Main Methods:
- Spray drying was employed to create SC-loaded biodegradable polymer powders (chitosan P₁ and chitosan/gum Arabic P₂).
- Formulations were characterized using techniques including DSC, SEM, particle size analysis, and flow/swelling tests.
- In vitro drug release and in vivo wound healing (excision and incision models) were evaluated, including histological assessment.
Main Results:
- Micronized SC powders showed no interaction with polymers, but exhibited poor flow and high moisture uptake.
- Formulations P₁ (chitosan/SC powder) and G₁ (chitosan/SC gel) demonstrated significant acceleration of excision wound healing, achieving 98.4% and 98.5% area reduction, respectively.
- Incision wound healing was improved with P₁, showing a tensile strength of 6.9 kg/cm² compared to 3.7 kg/cm² for the control.
Conclusions:
- Spray-dried chitosan/SC powder (P₁) and its gel formulation (G₁) show promise as effective wound healing promoters.
- Histological examinations support the positive outcomes observed in both excision and incision wound models.
