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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
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Recent advances in self-emulsifying drug delivery systems (SEDDS)
Bhupinder Singh1, Sarwar Beg2, Rajneet Kaur Khurana2
1University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India; UGC Centre of Excellence in Applications of Nanomaterials, Nanoparticles & Nanocomposites (Biomedical Sciences).
Critical Reviews in Therapeutic Drug Carrier Systems
|June 19, 2014
Summary
Self-emulsifying drug delivery systems (SEDDS) enhance oral bioavailability for poorly absorbed drugs. These systems also show promise for non-oral delivery and incorporate novel excipients for improved therapeutic outcomes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biopharmaceutics
Background:
- Poor oral bioavailability and inconsistent absorption present significant challenges in modern drug delivery.
- Self-emulsifying drug delivery systems (SEDDS) offer a promising solution due to their small droplet size, high drug solubilization, and formulation advantages.
Purpose of the Study:
- To provide an updated overview of novel self-emulsifying (SE) systems, including nanosized formulations.
- To review publications and patents on SE systems for both oral and non-oral therapeutic applications.
- To guide scientists in formulating diverse SE systems.
Main Methods:
- Review of recent publications and patents concerning self-emulsifying systems.
- Analysis of formulation strategies, including the use of functional excipients like polar lipids and polymers.
- Exploration of applications in oral and non-oral drug delivery.
Main Results:
- SEDDS improve oral bioavailability by enhancing drug solubility and absorption, inhibiting drug efflux pumps (P-gp), reducing first-pass metabolism, and facilitating lymphatic transport.
- SE systems have been successfully extended to non-oral delivery routes.
- Novel SE systems, often nanosized, utilize advanced excipients for enhanced performance.
Conclusions:
- SEDDS are versatile platforms for overcoming oral bioavailability challenges and expanding therapeutic applications.
- Innovative SE formulations, particularly nanosized ones with functional excipients, represent a significant advancement in drug delivery.
- This review serves as a resource for developing advanced SE systems for various therapeutic needs.
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