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Tumor plasticity interferes with anti-tumor immunity

Salem Chouaib1, Bassam Janji2, Andres Tittarelli1

  • 1Institut National de la Sante et de la Recherche Medicale (INSERM U753); Institut Federatif de Recherche 54 (IFR54); Institut de cancerologie Gustave Roussy. F-94800 Villejuif, France.

Critical Reviews in Immunology
|June 19, 2014
PubMed
Summary

Tumor cell plasticity, including epithelial-to-mesenchymal transition (EMT), drives cancer immune evasion and resistance. Targeting this plasticity offers a new strategy for more effective cancer immunotherapies.

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