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Updated: Apr 28, 2026
09:51
Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
Published on: May 18, 2018
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Regulation of Dendritic Cell Function by Dietary Polyphenols
Manuela del Cornò1, Beatrice Scazzocchio2, Roberta Masella2
1a Department of Hematology , Oncology and Molecular Medicine, Istituto Superiore di Sanità , Rome , Italy.
Critical Reviews in Food Science and Nutrition
|June 19, 2014
Summary
Dietary polyphenols, found in fruits and vegetables, can significantly impact immune function. This review explores how these compounds affect dendritic cells (DCs), crucial for immune responses, offering insights into diet-related health.
Area of Science:
- Nutritional Immunology
- Molecular Nutrition
- Immunology
Background:
- Global dietary shifts impact health and chronic disease development.
- Bioactive food compounds are explored for therapeutic potential in metabolic dysregulation.
- Diet's influence on the human immune system is an emerging area of research.
Purpose of the Study:
- To review the effects of polyphenols on immune system function.
- To outline the impact of polyphenols on dendritic cell (DC) biology.
- To understand how diet influences innate and adaptive immunity.
Main Methods:
- Literature review on polyphenol-diet-immunity interactions.
- Analysis of studies on polyphenol effects on dendritic cells (DCs).
- Examination of DC differentiation, maturation, and immune response modulation.
Main Results:
- Polyphenols are key regulators of cellular processes and body homeostasis.
- Polyphenols influence dendritic cell (DC) differentiation and maturation.
- DCs' capacity to induce immune tolerance or activation is modulated by polyphenols.
Conclusions:
- Dietary polyphenols play a critical role in modulating immune responses via dendritic cells (DCs).
- Understanding these interactions is vital for addressing global health challenges.
- Polyphenols represent a promising area for dietary interventions in immune health.
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