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Updated: Apr 28, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
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Bone scintigraphy in osteosarcoma: a single institution experience.

Jacquelyn M Powers1, Carrye Cost, Kevin Cederberg

  • 1Departments of *Pediatrics ∥Radiology, The University of Texas Southwestern Medical Center †Children's Medical Center, Dallas, TX ‡Department of Pediatrics, The University of Colorado, Denver §Colorado Children's Hospital, Aurora, CO.

Journal of Pediatric Hematology/Oncology
|June 20, 2014
PubMed
Summary
This summary is machine-generated.

Bone scintigraphy, a standard for detecting osteosarcoma metastasis, may not be necessary for routine surveillance. A review found cold bone scans rare, and symptomatic patients typically indicate recurrence.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Orthopedic Surgery

Background:

  • Bone scintigraphy is a common diagnostic tool for evaluating metastatic disease in osteosarcoma patients.
  • The utility of bone scintigraphy in routine post-treatment surveillance for osteosarcoma remains a subject of investigation.

Purpose of the Study:

  • To assess the frequency and significance of negative (cold) bone scans in osteosarcoma patients.
  • To evaluate the role of bone scintigraphy in routine surveillance for skeletal recurrence in osteosarcoma.

Main Methods:

  • Retrospective review of bone scintigraphy findings in osteosarcoma patients at a single institution.
  • Analysis of scan results at diagnosis and during skeletal recurrence.
  • Correlation of bone scan features with clinical outcomes and symptoms.

Main Results:

  • No cold bone scans were observed at the time of osteosarcoma diagnosis.
  • Only one patient (1/?) demonstrated a cold bone scan at skeletal recurrence.
  • No significant correlation was found between bone scan features and clinical outcomes, apart from detecting metastatic disease.

Conclusions:

  • Bone scintigraphy is not indicated for routine post-chemotherapy surveillance in osteosarcoma patients.
  • Symptomatic presentation is a more reliable indicator of skeletal recurrence in osteosarcoma.