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Related Experiment Video

Updated: Apr 28, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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Nanovalve activation by surface-attached photoacids.

T M Guardado-Alvarez1, M M Russell, J I Zink

  • 1Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095-1569, USA. zink@chem.ucla.edu.

Chemical Communications (Cambridge, England)
|June 20, 2014
PubMed
Summary

Light-activated photoacids on nanoparticles trigger molecular release from nanovalves. This pH-responsive system demonstrates externally controlled drug delivery using light activation.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Photochemistry

Background:

  • Mesoporous silica nanoparticles (MSNs) are widely used for drug delivery.
  • Controlling molecular release from MSNs remains a challenge.
  • Developing externally triggered release systems is crucial for targeted therapies.

Purpose of the Study:

  • To develop a light-responsive nanovalve system for controlled molecular release.
  • To investigate the mechanism of light-induced proton transfer for nanovalve activation.
  • To demonstrate pH-responsive molecular delivery using photoacid-functionalized MSNs.

Main Methods:

  • Synthesized photoacid-functionalized mesoporous silica nanoparticles.
  • Attached an aniline-based stalk and cyclodextrin to block nanoparticle pores.
  • Used UV light excitation to trigger proton transfer and nanovalve opening.
  • Analyzed the release of trapped molecules using spectroscopy.

Main Results:

  • Photoacid excitation induced proton transfer, leading to aniline stalk protonation.
  • Protonation caused the release of the cyclodextrin gatekeeper molecule.
  • Successfully demonstrated light-triggered release of encapsulated molecules from MSNs.
  • Confirmed the pH-responsive nature of the nanovalve system.

Conclusions:

  • Light-triggered proton transfer effectively activates nanovalves on MSNs.
  • Photoacid-functionalized MSNs provide a controllable platform for molecular delivery.
  • This system offers a novel approach for externally regulated drug release.