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Updated: Apr 28, 2026
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
Published on: August 30, 2017
Nanovalve activation by surface-attached photoacids
T M Guardado-Alvarez1, M M Russell, J I Zink
1Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095-1569, USA. zink@chem.ucla.edu.
Abstract:
Proton transfer caused by excitation of a photoacid attached to the surface of a mesoporous silica nanoparticle activates a nanovalve and causes release of trapped molecules. The protonation of an aniline-based stalk releases a noncovalently bound cyclodextrin molecule that blocked a pore. The results show that pH-responsive molecular delivery systems can be externally controlled using light.
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