Adenomatoid odontogenic tumor with clear cell changes

Area of Science:

• Oral pathology
• Odontogenic tumors
• Neoplastic pathology

Background:

• Adenomatoid odontogenic tumor (AOT) is an uncommon benign tumor of odontogenic origin.
• Its exact nature (hamartoma vs. neoplasm) and biological profile have been debated for decades.
• First widely accepted report by Harbitz in 1915.

Observation:

• A case of AOT in a 20-year-old female is presented.
• Detailed clinical, radiological, and histological features are described.
• The tumor exhibited unusual clear cell changes.

Findings:

• The presence of clear cell changes suggests AOT may be more aggressive than previously understood.
• An extensive literature search revealed no prior reports of clear cell changes in AOT.
• This finding challenges the established biological profile of AOT.

Implications:

• Clear cell changes in AOT may indicate a more aggressive clinical behavior.
• Further research is needed to understand the significance and implications of these histological variations.
• This case expands the histopathological spectrum of AOT and its potential clinical behavior.