Imaging preclinical tumour models: improving translational power

Area of Science:

• Biomedical Imaging
• Oncology Research
• Translational Medicine

Background:

• Multimodal imaging techniques for in vivo cancer research have advanced significantly.
• Developments in probe synthesis and labeling offer new tools for basic, translational, and clinical applications.
• Sophisticated cancer models are increasingly available for research.

Purpose of the Study:

• To review recent advancements in multimodal imaging, probe development, and cancer models for in vivo research.
• To highlight the role of imaging in animal cancer models for therapy translation.
• To provide an overview of progress in these three key areas.

Main Methods:

• Review of recent literature on multimodal imaging in animal cancer models.
• Analysis of technological developments in imaging probe synthesis and labeling.
• Examination of advancements in cancer model development for research.

Main Results:

• Multimodal imaging offers enhanced in vivo visualization of cancer processes.
• Novel imaging probes show potential for diverse research and clinical applications.
• Improved cancer models facilitate the study of complex cancer-related questions.

Conclusions:

• Recent progress in imaging, probes, and models significantly enhances cancer research capabilities.
• Imaging in animal models is crucial for translating new cancer therapies to the clinic.
• These integrated developments promise to accelerate cancer treatment advancements.