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The X-ray structure of the complex formed in the reaction between oxaliplatin and lysozyme
Luigi Messori1, Tiziano Marzo, Antonello Merlino
1Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
Chemical Communications (Cambridge, England)
|June 20, 2014
Abstract:
The X-ray structure of the adduct formed between oxaliplatin and the model protein hen egg white lysozyme is reported here. The structure is compared with those of cisplatin and carboplatin derivatives, previously solved. Relevant changes are highlighted among these crystal structures that are suggestive of significant differences in the reactivity of platinum drugs with this protein; possible biological implications are discussed.
