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Stability of transcription complexes on class II genes
M W Van Dyke1, M Sawadogo, R G Roeder
1Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021.
Molecular and Cellular Biology
|January 1, 1989
Abstract:
Commitment of a TATA box-driven class II gene to transcription requires binding of only one transcription factor, TFIID. Additional factors (TFIIB, TFIIE, and RNA polymerase II) do not remain associated with the TFIID-promoter complex during the course of transcription. This indicates that there are two intermediates along the transcription reaction pathway which may be potential targets for the regulation of gene expression.