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Updated: Apr 27, 2026

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
Published on: June 21, 2024
Evaluation of an every-other-day palonosetron schedule to control emesis in multiple-day high-dose chemotherapy
Aurora Mirabile1, Luigi Celio, Michele Magni
1Department of Medical Oncology, Fondazione IRCCS 'Istituto Nazionale Tumori', Milan, Italy.
Aim:
Efficacy of intermittent palonosetron dosing in patients undergoing multiple-day, high-dose chemotherapy (HDC) was investigated.
Patients & Methods:
Fifty-eight patients received palonosetron (0.25 mg intravenous [iv.]) every other day plus daily dexamethasone (8 mg iv. twice daily) dosing. The primary end point was complete control (CC; no emesis, no rescue anti-emetics, and no more than mild nausea) in the overall acute-period (until 24 h after chemotherapy completion).
Results:
Acute-period CC occurred in 81% and 50% of patients receiving palonosetron and ondansetron (historical control cohort), respectively. Palonosetron (odds ratio [OR]: 4.37; p = 0.001) and a longer duration of HDC regimen (OR: 3.47; p = 0.011) independently predicted a better anti-emetic outcome.
Conclusion:
Palonosetron every other day plus daily dexamethasone is an effective anti-emetic coverage in patients undergoing HDC.
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