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High-throughput production of two disulphide-bridge toxins
Grégory Upert1, Gilles Mourier, Alexandra Pastor
1CEA, DSV, iBiTec-S, Service d'Ingénierie Moléculaire des Protéines (SIMOPRO), CEA Saclay, Gif sur Yvette F-91191, France. gregory.upert@cea.fr nicolas.gilles@cea.fr.
Chemical Communications (Cambridge, England)
|June 21, 2014
Abstract:
A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies.