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Published on: October 25, 2024
PET/CT imaging in cancer: current applications and future directions
Michael D Farwell1, Daniel A Pryma, David A Mankoff
1Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Positron emission tomography/computed tomography (PET/CT) offers quantitative imaging for cancer research and clinical practice. This review covers current applications and future directions for PET/CT in oncology, including novel imaging agents and targets.
Area of Science:
- Oncology
- Medical Imaging
- Radiochemistry
Background:
- Positron emission tomography (PET) provides quantitative in vivo imaging of biology and biochemistry.
- PET/CT combines PET with computed tomography for enhanced oncologic applications.
- PET/CT is crucial in clinical practice and translational cancer research.
Purpose of the Study:
- To review current applications of PET/CT in cancer.
- To discuss future directions and emerging PET/CT methods for cancer imaging.
- To highlight PET/CT's role in clinical practice and trials.
Main Methods:
- Review of basic PET principles and (18)F-fluorodeoxyglucose (FDG) biochemistry.
- Discussion of current clinical applications of FDG PET/CT in oncology.
- Exploration of emerging PET imaging methods for cancer biology.
Main Results:
- FDG PET/CT is a cornerstone of oncologic imaging.
- Emerging PET tracers target cellular proliferation, hypoxia, apoptosis, metabolism, and gene products.
- Focus on clinically translated and trial-stage PET/CT methods.
Conclusions:
- PET/CT has significantly impacted cancer diagnosis, staging, and treatment monitoring.
- Advancements in PET tracers promise more precise and personalized cancer management.
- Continued research and clinical trials are vital for expanding PET/CT's role in oncology.
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