Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cidex-induced synovitis.

C D Harner1, F H Fu, G C Mason

  • 1Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh, Pennsylvania.

The American Journal of Sports Medicine
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In search of a gold standard for objective clinical outcome: using dynamic biplane radiography to measure knee kinematics.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2021
Same author

First Report of Coleus blumei viroid 2 from Commercial Coleus in China.

Plant disease·2019
Same author

First Report of Coleus blumei viroid 5 from Coleus blumei in India and Indonesia.

Plant disease·2019
Same author

Anatomic double bundle ACL reconstruction outperforms any types of single bundle ACL reconstructions in controlling dynamic rotational laxity.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2017
Same author

Possibilities of gene therapy in traumatic and degenerative lesions of the joints. Current experimental status and preliminary clinical applications.

Der Orthopade·2017
Same author

Sportsmedicine forum.

The Physician and sportsmedicine·2016
Same journal

Reliability and Clinical Validity of a Morphology-Based Classification System for Radial Meniscal Tears: A Multicenter Observer Study.

The American journal of sports medicine·2026
Same journal

Comparison of Long-term Supraspinatus Tear Progression After Arthroscopic Isolated Subscapularis Repair With and Without Comma Tissue Preservation: A Minimum 10-Year MRI Follow-up Study.

The American journal of sports medicine·2026
Same journal

The Long-term Radiographic Fate of the Chronically ACL-Deficient Knee: Response.

The American journal of sports medicine·2026
Same journal

The Long-term Radiographic Fate of the Chronically ACL-Deficient Knee: Letter to the Editor.

The American journal of sports medicine·2026
Same journal

Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic RC Repair: Letter to the Editor.

The American journal of sports medicine·2026
Same journal

Metformin Reduces the Incidence of Shoulder Stiffness After Arthroscopic RC Repair: Response.

The American journal of sports medicine·2026
See all related articles

Glutaraldehyde (Cidex) causes chemical synovitis in rabbit knees, with inflammation severity increasing with concentration. Proper double-rinsing techniques significantly reduce Cidex levels, preventing joint inflammation.

Area of Science:

  • Orthopedics
  • Biomaterials Science
  • Toxicology

Background:

  • Glutaraldehyde (Cidex) is a high-level disinfectant used in arthroscopic surgery.
  • Concerns exist regarding potential intra-articular toxicity from residual disinfectant.
  • Understanding Cidex's effects on synovial tissue is crucial for patient safety.

Purpose of the Study:

  • To evaluate the synovial response to varying concentrations of glutaraldehyde (Cidex).
  • To determine the relationship between Cidex concentration and the severity of induced synovitis.
  • To assess the effectiveness of different rinsing protocols in mitigating Cidex toxicity.

Main Methods:

  • Rabbit knees were injected with different concentrations of Cidex (10 ppm to 100+ ppm).
  • Synovial tissue was examined microscopically for inflammatory changes.

Related Experiment Videos

  • Intraoperative rinse solutions were analyzed for Cidex concentrations.
  • The impact of single versus double rinsing techniques was investigated.

    • Main Results:

    • Microscopic inflammation, including hypertrophy and edema, was observed at 10 ppm Cidex.
    • Higher concentrations (100+ ppm) induced necrosis, hemorrhage, and diffuse synovitis.
    • Inflammation severity correlated directly with Cidex concentration.
    • Single-use rinse solutions reached up to 300 ppm, increasing to 1000 ppm with reuse.
    • Double-rinsing protocols reduced second rinse concentrations to below 10 ppm.

    Conclusions:

    • Glutaraldehyde induces a dose-dependent chemical synovitis, not an allergic reaction.
    • Single-use rinsing protocols can lead to significant intra-articular Cidex exposure.
    • Double-rinsing, with changes between cases, effectively minimizes residual Cidex and prevents joint inflammation.