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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
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Pathogenicity of Shigella in chickens
1Collage of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, People's Republic of China.
Plos One
|June 21, 2014
Summary
Shigella bacteria can infect chickens, causing illness and even death. This research suggests a potential for human-poultry cross-infection, highlighting public health concerns regarding Shigella transmission.
Area of Science:
- Veterinary Microbiology
- Infectious Diseases
- One Health
Background:
- Shigellosis, a bacterial infection, was first documented in chickens in 2004.
- Understanding Shigella pathogenicity in poultry is crucial for public health and food safety.
Purpose of the Study:
- To investigate the pathogenicity of Shigella in chickens.
- To explore the potential for cross-infection between humans and chickens with Shigella.
Main Methods:
- Infection of specific-pathogen-free (SPF) chickens with a human-derived Shigella strain (ZD02).
- Examination of virulence and invasiveness in chicken intestines and primary chicken intestinal epithelial cells.
- Utilized immunohistochemistry and transmission electron microscopy for cellular and tissue analysis.
Main Results:
- Shigella caused mortality in SPF chickens via intraperitoneal injection and depression via crop injection.
- Demonstrated Shigella invasion of chicken intestinal epithelia in vivo and in primary epithelial cells in vitro.
- Confirmed bacterial internalization within phagosome-like membranes in epithelial cells.
Conclusions:
- Shigella exhibits pathogenicity in chickens, capable of invading intestinal tissues and causing severe outcomes.
- Shigella strains from humans and poultry share similar pathogenic potential.
- Findings indicate a significant possibility of human-poultry cross-infection, posing a public health risk.
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