Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

44
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
44
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

3.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishment of a clear cell renal cell carcinoma organoid cohort integrated into the UroCCR clinical database: A feasibility study.

Translational oncology·2026
Same author

The Hippo pathway in clear cell renal cell carcinoma (ccRCC): a nexus with the VHL disruption?

Translational oncology·2026
Same author

Photocoagulation with GREENLIGHT© laser in radiation-induced haemorrhagic cystitis: Results of a single-center series.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023
Same author

Factors Associated With Genotypic Resistance and Outcome Among Solid Organ Transplant Recipients With Refractory Cytomegalovirus Infection.

Transplant international : official journal of the European Society for Organ Transplantation·2023
Same author

[Which non pharmacological interventions should be offered to patients treated with androgen deprivation therapy for prostate cancer? A systematic review].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023
Same author

Specificities of Meningitis and Meningo-Encephalitis After Kidney Transplantation: A French Retrospective Cohort Study.

Transplant international : official journal of the European Society for Organ Transplantation·2023
Same journal

["Connected device for monitoring patients treated by prostatectomy: Implementation and qualitative assessment"].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2024
Same journal

[Role of nurses specializing in oncology to support the care journey for patients with penile cancer].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2024
Same journal

[Pre- and post-prostatectomy rehabilitation by the certified nurse-urologist pair (REHAB): Feasibility study].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2024
Same journal

[Genitourinary complications after pelvic radiotherapy: Diagnosis and management].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2024
Same journal

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023
Same journal

[Male contraception].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

11.1K

Ischemic pre- and post-conditioning: current clinical applications.

R Thuret1, T Saint Yves2, X Tillou3

  • 1Inserm U1082; université de Poitiers, faculté de Médecine et Pharmacie, 86000 Poitiers, France; Service d'Urologie et de Transplantation rénale, hôpital Lapeyronie, 34295 Montpellier, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|June 22, 2014
PubMed
Summary
This summary is machine-generated.

Ischemic conditioning protects organs from damage by brief ischemia-reperfusion. While effective in cardiac surgery, its use in organ transplantation, particularly liver and kidney, requires further research in large animal and human models.

Keywords:
Conditionnement ischémiqueIschemia-reperfusion injuriesIschemic conditioningKidney transplantationLésions d’ischémie reperfusionTransplantation rénale

More Related Videos

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.0K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.2K

Related Experiment Videos

Last Updated: Apr 27, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

11.1K
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

12.0K
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

7.2K

Area of Science:

  • Organ transplantation
  • Ischemia-reperfusion injury
  • Cellular protection mechanisms

Background:

  • Ischemic conditioning, observed since the 1980s, protects organs via brief ischemia-reperfusion.
  • It offers local, remote, direct, or pharmacological approaches with varying protection timelines.
  • Transplantation benefits from controlled ischemia/reperfusion, potentially improving graft survival and function.

Purpose of the Study:

  • To review the phenomenon of ischemic conditioning.
  • To explore its potential applications and underlying mechanisms in organ transplantation.
  • To assess the current status of research, particularly in liver and kidney transplantation.

Main Methods:

  • Review of existing literature on ischemic conditioning.
  • Analysis of protective pathways including energy preservation, oxidative stress reduction, and apoptosis inhibition.
  • Examination of pharmacological conditioning strategies using common drugs like anesthetics.

Main Results:

  • Ischemic conditioning demonstrates significant protective effects in small animal models.
  • Pharmacological conditioning shows promise in mimicking protective effects without vessel clamping.
  • Human and large animal studies in liver and kidney transplantation remain inconclusive.

Conclusions:

  • Ischemic conditioning presents a promising strategy for mitigating ischemia-reperfusion injury in organ transplantation.
  • Further investigation in large animal models and human clinical trials is crucial for liver and kidney transplantation.
  • Understanding and optimizing conditioning protocols could enhance graft viability and patient outcomes.