Related Experiment Video
Updated: Apr 27, 2026
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
1.5K
Urinary nerve growth factor in patients with detrusor overactivity
A Korzeniecka-Kozerska1, A Wasilewska2
1Department of Pediatrics and Nephrology, Medical University of Bialystok, 17 Waszyngtona Street, 15-274, Bialystok, Poland. agatakozerska@poczta.onet.pl.
Irish Journal of Medical Science
|June 22, 2014
Summary
Urinary nerve growth factor (NGF) levels are higher in children with detrusor overactivity (DO). Measuring urinary NGF is a simple, noninvasive method to detect DO and guide therapy in pediatric patients.
Area of Science:
- Pediatric Urology
- Biochemistry
- Clinical Diagnostics
Background:
- Detrusor overactivity (DO) is a common pediatric bladder dysfunction.
- Current diagnosis requires invasive urodynamic investigation.
- Nerve growth factor (NGF) is implicated in bladder function.
Purpose of the Study:
- To compare urinary NGF (uNGF) levels in children with DO versus healthy controls.
- To assess the potential of uNGF as a noninvasive biomarker for pediatric DO.
Main Methods:
- Study included 44 children (24 with DO, 20 healthy).
- Uroflowmetry performed on all participants; cystometry on DO patients.
- Urinary NGF (uNGF) levels were measured in both groups.
Main Results:
- Median uNGF levels were significantly higher in children with DO before treatment.
- No significant difference in uNGF levels after anticholinergic therapy compared to controls.
- Correlations observed between uroflowmetry parameters and uNGF/creatinine levels.
Conclusions:
- Urinary NGF levels show potential as a noninvasive marker for detecting DO in children and adolescents.
- uNGF measurement offers a simple, noninvasive diagnostic tool for guiding therapy in pediatric DO.
More Related Videos
Related Concept Videos
01:26The Micturition Reflex
4.0K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
4.0K
01:23Urinary Bladder
4.6K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
4.6K
01:21Nursing Assessment of the Genitourinary System I: Health History
809
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
809
01:19Urodynamic Studies: Uroflowmetry
9.4K
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
9.4K
01:30Urinary Tract Calculi III: Medical Management
397
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
397
01:28Microbiota of the Urogenital Tract
52
The human urogenital system, once thought to be sterile in healthy individuals, is now recognized as a complex microbial habitat. Advancements in molecular sequencing techniques have revealed that even in healthy adults, the kidneys and bladder harbor microbial populations similar to those found in the distal urethra, albeit in much lower abundance. These resident microorganisms, while generally innocuous, can become opportunistic pathogens under conditions that alter the urogenital...
52