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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
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Nailfold capillaroscopy in acrocyanosis among patients with associated Raynaud's phenomenon.

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Related Experiment Video

Updated: Apr 27, 2026

Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy
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Non-Invasive Visualization of Nailbed Microvascular Morphology in Mice Using Capillaroscopy

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[Nail-fold capillaroscopy in dermatology].

P Senet1, F Fichel1, N Baudot1

  • 1Service de dermatologie, UF de dermatologie vasculaire, hôpital Tenon, 4, rue de la Chine, 75970 Paris cedex 20, France.

Annales De Dermatologie Et De Venereologie
|June 22, 2014
PubMed
Summary

Nail-fold capillaroscopy, a non-invasive technique, aids in diagnosing microcirculation disorders. It helps differentiate primary Raynaud phenomenon from systemic sclerosis, predicting complications and guiding differential diagnoses in connective tissue diseases.

Keywords:
CapillaroscopieConnective tissue diseaseConnectivitesNail-fold capillaroscopyPaysage sclérodermiquePhénomène de RaynaudRaynaud phenomenonSclerodermic patternSclérodermieSystemic sclerosis

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Area of Science:

  • Microcirculation studies
  • Dermatology, angiology, and rheumatology applications
  • Non-invasive diagnostic imaging

Context:

  • Video-capillaroscopy enables digital image storage for longitudinal patient monitoring.
  • Nail-fold capillaroscopy assesses microvascular changes in connective tissue diseases.
  • Distinguishes normal patterns from sclerodermic patterns indicative of systemic sclerosis.

Purpose:

  • To highlight the diagnostic and prognostic value of nail-fold capillaroscopy.
  • To differentiate primary Raynaud phenomenon from secondary Raynaud phenomenon.
  • To assess risk for digital ulcers and visceral complications in systemic sclerosis.

Summary:

  • Qualitative and quantitative analysis of nail-fold capillaries differentiates primary and secondary Raynaud phenomenon.
  • Identifies sclerodermic patterns associated with high risk of systemic sclerosis.
  • Video-capillaroscopy facilitates tracking of capillaroscopic abnormalities over time.

Impact:

  • Essential for differential diagnosis of connective tissue diseases.
  • Crucial for etiologic diagnosis of digital necrosis and interstitial lung disease.
  • Predicts risk of digital ulcers and systemic complications in scleroderma patients.