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Related Experiment Videos

Hyperalimentation in cancer.

W W Souba1, E M Copeland

  • 1University of Florida College of Medicine, Gainesville.

CA: a Cancer Journal for Clinicians
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Total parenteral nutrition (TPN) is recommended for cancer patients with high nutritional morbidity and unavailable gastrointestinal tracts, but not for terminally ill patients. Careful patient selection is crucial for effective cancer treatment.

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Mechanisms governing the expression of the enzymes of glutamine metabolism--glutaminase and glutamine synthetase.

The Journal of nutrition·2001

Area of Science:

  • Oncology
  • Nutritional Support

Background:

  • Malnutrition is a significant concern in cancer patients undergoing treatment.
  • Nutritional morbidity can be high, impacting treatment response and patient outcomes.
  • The gastrointestinal tract's availability is a key factor in determining nutritional support needs.

Purpose of the Study:

  • To evaluate the role and indications of Total Parenteral Nutrition (TPN) in cancer care.
  • To address concerns regarding malnutrition and its impact on antineoplastic therapy.
  • To explore the potential of TPN in optimizing nutrient composition for cancer treatment.

Main Methods:

  • Review of clinical judgment criteria for TPN candidate selection.
  • Analysis of TPN's role when the gastrointestinal tract is unavailable.

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  • Examination of TPN's potential in exploring alternative nutrient-based therapies.

    • Main Results:

    • TPN is indicated when response rates to antineoplastic therapy are good and nutritional morbidity is high, provided the GI tract is unavailable.
    • Prolongation of suffering in terminally ill cancer patients is not an indication for TPN.
    • Stimulation of tumor growth by TPN is not scientifically documented in patient populations.

    Conclusions:

    • Appropriate clinical judgment is essential for selecting TPN candidates, typically those with malnutrition and GI tract failure.
    • TPN allows for controlled nutrient manipulation, potentially aiding in the development of novel cancer therapies.
    • Concerns about TPN stimulating tumor growth lack scientific documentation and are not supported by widespread clinical use.