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Clearance of plasma proprotein convertase subtilisin/kexin 9 by low-density lipoprotein apheresis

P B Duell1, Genevieve Dubuc2, Nabil G Seidah3

  • 1Oregon Health & Science University, Portland.

Circulation Research
|June 22, 2014
PubMed
Abstract

No abstract available in PubMed .

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Hepatic Drug Clearance: Effect of Protein Binding01:09

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Hepatic clearance is influenced by protein binding based on the drug's extraction ratio. Drugs with high extraction ratios are considered flow-limited and remain unaffected by protein binding during hepatic clearance. On the other hand, drugs with low extraction ratios may be impacted by plasma protein binding, although the extent of this influence depends on the fraction of the drug bound.
For low-extraction-ratio drugs that are less than 80% protein-bound, minor changes in protein binding...
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