Related Experiment Video
Updated: Apr 27, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Hypotensive effect of retabolil correcting the concentration of aldosterone during stress exposures
T A Obut1, M V Ovsyukova, S A Egorova
1Research Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Abstract:
Male rats were exposed to single or repeated (19 days) cold treatment (4°C) and non-cold stress (60-min shaking on a laboratory shuttle device). Retabolil had a hypotensive effect, which was accompanied by the prevention of a stress-induced increase in the concentration of a hypertensive hormone aldosterone. Under conditions of repeated stress, these effects were realized via μ-opioid receptors. Our results suggest that retabolil can be used as a hypotensive and aldosterone-blocking agent, at least during stress exposure in animals (and probably in humans).
Related Concept Videos
Antihypertensive Drugs: Action of β1 Blockers
Antihypertensive Drugs: Direct Renin Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Hormonal Regulation
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

