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Increased serum cathepsin K in patients with coronary artery disease
Xiang Li1, Yuzi Li1, Jiyong Jin1
1Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China.
Insights
Serum Cathepsin K (CatK) levels are elevated in patients with coronary artery disease (CAD). Elevated CatK is a significant biomarker for CAD prevalence and severity.
Area of Science:
- Cardiovascular Research
- Biomarker Discovery
- Vascular Biology
Background:
- Cathepsin K (CatK) is a collagenase linked to atherosclerosis and vascular remodeling.
- Understanding CatK's role in coronary artery disease (CAD) is crucial for risk assessment.
Purpose of the Study:
- To investigate the association between serum CatK levels and the prevalence of CAD.
- To determine if CatK can serve as a biomarker for CAD.
Main Methods:
- Serum CatK, hs-CRP, and HDL cholesterol levels were measured in 256 CAD patients and 129 controls.
- Coronary angiography and percutaneous coronary intervention data were utilized.
- Regression analyses assessed the relationship between CatK and CAD predictors.
Main Results:
- CAD patients exhibited significantly higher serum CatK levels than controls (130.8 vs. 86.9 ng/mL).
- Acute coronary syndrome patients had higher CatK than stable angina patients (137.1 vs. 102.6 ng/mL).
- CatK levels correlated inversely with HDL and positively with hs-CRP, independently predicting CAD.
Conclusions:
- Elevated serum CatK levels are strongly associated with the presence and severity of CAD.
- Circulating CatK is a potential and valuable biomarker for diagnosing and assessing CAD risk.
Purpose:
Cathepsin K is a potent collagenase implicated in human and animal atherosclerosis-based vascular remodeling. This study examined the hypothesis that serum CatK is associated with the prevalence of coronary artery disease (CAD).
Materials And Methods:
Between January 2011 and December 2012, 256 consecutive subjects were enrolled from among patients who underwent coronary angiography and percutaneous coronary intervention treatment. A total of 129 age-matched subjects served as controls.
Results:
The subjects' serum cathepsin K and high sensitive C-reactive protein (hs-CRP) and high-density lipoprotein cholesterol were measured. The patients with CAD had significantly higher serum cathepsin K levels compared to the controls (130.8±25.5 ng/mL vs. 86.9±25.5 ng/mL, p<0.001), and the patients with acute coronary syndrome had significantly higher serum cathepsin K levels compared to those with stable angina pectoris (137.1±26.9 ng/mL vs. 102.6±12.9 ng/mL, p<0.001). A linear regression analysis showed that overall, the cathepsin K levels were inversely correlated with the high-density lipoprotein levels (r=-0.29, p<0.01) and positively with hs-CRP levels (r=0.32, p<0.01). Multiple logistic regression analyses shows that cathepsin K levels were independent predictors of CAD (odds ratio, 1.76; 95% confidence interval, 1.12 to 1.56; p<0.01).
Conclusion:
These data indicated that elevated levels of cathepsin K are closely associated with the presence of CAD and that circulating cathepsin K serves a useful biomarker for CAD.
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