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Expanding the Toolkit for In Vivo Imaging of Axonal Transport
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Prototype nerve-specific near-infrared fluorophores.

Min Ho Park1, Hoon Hyun2, Yoshitomo Ashitate3

  • 11. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215. ; 2. Department of Surgery, Chonnam National University Medical School, Gwangju 501-746, South Korea.

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Summary

Researchers developed new near-infrared (NIR) fluorescent dyes, like Oxazine 4, to help surgeons see and preserve nerves during operations. This imaging technology aims to reduce nerve damage and improve patient outcomes by highlighting critical nerve structures.

Keywords:
Real-time intraoperative identificationcontrast agentsnear-infrared imaging.nerve targetingrecurrent laryngeal nervetargeted agents

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Area of Science:

  • Biomedical Engineering
  • Surgical Innovation
  • Medical Imaging

Background:

  • Nerve preservation is critical in surgery to prevent patient morbidity.
  • Current nerve identification relies on visual inspection and anatomy, lacking real-time guidance.
  • Developing nerve-specific imaging agents is essential for intraoperative nerve avoidance.

Purpose of the Study:

  • To evaluate Oxazine derivatives as nerve-specific near-infrared (NIR) fluorophores.
  • To assess the potential of these agents for real-time intraoperative nerve visualization.
  • To improve surgical safety and reduce nerve-related complications.

Main Methods:

  • Synthesis and evaluation of Oxazine derivatives for NIR fluorescence.
  • Intravenous injection of fluorophores in small and large animal models.
  • Real-time imaging of peripheral nerves (brachial plexus, sciatic, recurrent laryngeal) during simulated surgical procedures.

Main Results:

  • Oxazine 4 demonstrated nerve-targeted NIR signal in brachial plexus and sciatic nerves up to 12 hours post-injection.
  • Recurrent laryngeal nerves were successfully visualized in real-time in swine models.
  • The developed fluorophores show promise for intraoperative nerve identification.

Conclusions:

  • Oxazine derivatives, particularly Oxazine 4, show potential as nerve-specific NIR imaging agents.
  • This technology could enable real-time nerve identification and preservation during surgery.
  • Further optimization of optical properties will enhance the clinical utility of these nerve-targeting fluorophores.