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Updated: Apr 27, 2026

Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
Published on: May 2, 2020
The decrease in aqueous tear production associated with pepper spray.
Rifat Rasier1, Amber Senel Kukner, Elvan Alper Sengul
1Department of Ophthalmology, TC. Istanbul Bilim University , Istanbul , Turkey.
Pepper spray significantly reduces tear production and corneal sensitivity, especially without eye protection. Wearing protective goggles is crucial to minimize these effects from oleoresin capsicum exposure.
Area of Science:
- Ophthalmology
- Toxicology
- Forensic Science
Background:
- Pepper spray, containing oleoresin capsicum, causes significant ocular irritation and temporary visual impairment.
- Understanding its effects on tear production and corneal sensitivity is vital for both civilian and law enforcement safety.
Purpose of the Study:
- To investigate the impact of pepper spray exposure on lacrimal tear production and corneal sensitivity.
- To assess the effectiveness of protective eyewear in mitigating these effects.
Main Methods:
- Ninety-six individuals exposed to pepper spray during protests volunteered for the study.
- Data collected included use of protective goggles, eye irrigation, and dry eye symptoms via questionnaire.
- Schirmer I and II tests were conducted to measure tear production.
Main Results:
- Unprotected subjects showed significantly lower Schirmer test results compared to those wearing goggles.
- While Schirmer I and II results differed in protected subjects, they did not in unprotected ones.
- Dry eye symptoms were reported by 35% of unprotected and 24% of protected individuals.
Conclusions:
- Protective eyewear is essential to minimize direct pepper spray contact with the eyes.
- Reduced tear production in unprotected individuals may indicate potential long-term sensory alterations.
- Findings suggest the importance of protective measures against oleoresin capsicum exposure.
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