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Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
Published on: August 8, 2022
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Self-setting calcium orthophosphate formulations
1Kudrinskaja sq. 1-155, Moscow 123242, Russia. sedorozhkin@yandex.ru.
Journal of Functional Biomaterials
|June 24, 2014
Summary
Self-setting calcium orthophosphate cements are bioactive, biodegradable bioceramics for bone grafting. These versatile materials offer excellent moldability and support new bone formation, revolutionizing synthetic bone graft applications.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Materials Chemistry
Background:
- Calcium orthophosphate cements (COPCs) are bioactive and biodegradable materials.
- They were discovered in the early 1980s as powder-liquid formulations.
- COPCs set into hydroxyapatite or brushite, both biocompatible and osteoconductive.
Purpose of the Study:
- To provide an overview of self-setting calcium orthophosphate formulations.
- To highlight their suitability for dental and bone grafting applications.
- To discuss their properties and advantages in bone regeneration.
Main Methods:
- Review of existing literature on self-setting calcium orthophosphate cements.
- Analysis of their chemical composition, setting mechanisms, and biological properties.
- Evaluation of their clinical applications and potential for future development.
Main Results:
- Self-setting COPCs exhibit excellent biocompatibility, bioresorbability, and osteoconductivity.
- These cements offer superior handling, molding capabilities, and adaptation to bone defects.
- Reinforced formulations (concretes) and drug/cell-loading capabilities have been developed.
Conclusions:
- Self-setting calcium orthophosphate formulations represent a significant advancement in synthetic bone grafts.
- Their properties make them highly promising for both dental and orthopedic applications.
- Continued research and development are expanding their use in regenerative medicine and tissue engineering.
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