Plant-Derived Polynucleotides/Polydeoxyribonucleotides in Skin Biomaterials: Delivery Platforms and Bioactivity...

Area of Science:

• Dermatology and skin biomaterials research.
• Focus on polynucleotides (PN) and polydeoxyribonucleotides (PDRN).

Background:

• Polynucleotides (PN) and polydeoxyribonucleotides (PDRN) are DNA-based polymers.
• Plant-derived PN/PDRN from cell cultures are emerging as animal-free biomaterials.
• Current evidence is largely preclinical and not equivalent to animal-derived PDRN.

Purpose of the Study:

• Synthesize recent reports on plant-derived and non-animal PN/PDRN.
• Integrate findings with skin biomaterial delivery platforms.
• Distinguish demonstrated findings from inferences and establish clear molecular definitions.

Main Methods:

• Review of recent preclinical and biomaterial delivery literature.
• Emphasis on molecular definitions, purity, integrity, and degradation.
• Analysis of delivery matrices and hypothesis-matched controls.

Main Results:

• Plant-derived PN/PDRN show overlapping biological signatures with classical PDRN (e.g., keratinocyte repair, ECM remodeling).
• A2A receptor dependency for plant-derived PN/PDRN is largely unestablished and remains a hypothesis.
• Limited direct head-to-head studies exist comparing plant-derived and animal-derived PDRN.

Conclusions:

• Plant-derived PN/PDRN require comprehensive evaluation as a source-process-structure-platform-function system.
• Direct clinical equivalence to animal-derived PDRN is not yet demonstrated.
• Further research with standardized methodologies is needed to validate efficacy and mechanisms.