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Adjustable intraocular lens power technology.

Joshua Ford1, Liliana Werner1, Nick Mamalis1

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This review covers adjustable intraocular lens (IOL) technologies, including surgical and non-invasive options. It details the research status of various adjustable IOLs, focusing on the light-adjustable lens (LAL).

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Materials Science

Background:

  • Adjustable intraocular lens (IOL) technologies are advancing to improve visual outcomes post-cataract surgery.
  • Current research focuses on developing IOLs with enhanced postoperative adjustability.
  • No financial or proprietary interests were disclosed by the authors.

Purpose of the Study:

  • To provide a comprehensive overview of current and emerging adjustable intraocular lens (IOL) technologies.
  • To describe the principles, research status, and adjustability methods of various IOLs.
  • To discuss the clinical evaluation of the light-adjustable lens (LAL).

Main Methods:

  • Review of available and under-development adjustable IOL technologies.
  • Categorization based on adjustment methods: secondary surgical procedures, non-invasive postoperative adjustments, and laser/chemistry-based adjustments.
  • Discussion of preclinical and clinical studies, including the light-adjustable lens (LAL).

Main Results:

  • Several adjustable IOL technologies are available or in development, including multicomponent, mechanically adjustable, repeatedly adjustable, magnetically adjustable, and liquid crystal IOLs.
  • Non-invasive adjustment methods and femtosecond laser or 2-photon chemistry are emerging.
  • The light-adjustable lens (LAL) is commercially available in some regions and undergoing US clinical evaluation.

Conclusions:

  • A diverse range of adjustable IOL technologies exists, offering various methods for visual correction.
  • Postoperative adjustability is a key area of innovation in IOL technology.
  • Further clinical evaluation, particularly for the LAL, will determine the future impact of these advancements.