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Campylobacter pylori gastritis: long term results of treatment with amoxycillin
G Oderda1, D Dell'Olio, I Morra
1Gastroenterology Service, Department of Paediatrics, University of Turin, Italy.
Insights
Amoxycillin alone is ineffective for long-term eradication of Campylobacter pylori (C. pylori) in children with gastritis. While initially effective, C. pylori infection and gastritis frequently recurred within three months.
Area of Science:
- Gastroenterology
- Pediatric Infectious Diseases
- Microbiology
Background:
- Gastritis in children is often associated with Helicobacter pylori infection.
- Campylobacter pylori (now known as Helicobacter pylori) was investigated for its role in pediatric gastritis.
- Understanding effective treatment strategies for H. pylori eradication is crucial for managing pediatric gastritis.
Purpose of the Study:
- To assess the efficacy of amoxycillin in eradicating Campylobacter pylori in children with gastritis.
- To evaluate the short-term and long-term outcomes of amoxycillin treatment on H. pylori infection and gastritis.
- To explore the recurrence rates of H. pylori and gastritis after amoxycillin therapy.
Main Methods:
- Endoscopic biopsy specimens were collected from the antral mucosa of 40 children diagnosed with gastritis.
- Samples were analyzed for Campylobacter pylori presence before, immediately after, and three months post-treatment.
- Treatment involved amoxycillin, with follow-up assessments conducted at specified intervals.
Main Results:
- Immediately after amoxycillin treatment, 85% of children showed no detectable C. pylori, and 58% had healed gastritis.
- However, within three months, C. pylori recurred in 73% of patients, with all experiencing gastritis relapse.
- A family history of peptic ulcer disease was significantly associated with C. pylori recurrence.
Conclusions:
- Amoxycillin monotherapy demonstrates short-term efficacy but is ineffective for the long-term eradication of C. pylori.
- High recurrence rates of both infection and gastritis suggest the need for alternative or combination treatment strategies.
- Family history may indicate a predisposition to persistent or recurrent H. pylori infections in pediatric populations.
Abstract:
To evaluate the efficacy of amoxycillin in eradicating Campylobacter pylori, endoscopic biopsy specimens were taken from the antral mucosa of 40 children with gastritis before, immediately after, and (in 30 patients) three months after treatment. Immediately after treatment 34 patients (85%) no longer had the organism in the mucosa, and the gastritis had healed in 23 (58%). Three months later the infection had recurred in 22 of 30 patients (73%), and the gastritis had relapsed in all of them. Significantly more children in whom C pylori recurred had family histories of peptic ulcer disease. The results suggest that amoxycillin alone is ineffective in the long term treatment of C pylori gastritis.