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The gene expression database for mouse development (GXD): putting developmental expression information at your

Constance M Smith1, Jacqueline H Finger, James A Kadin

  • 1The Jackson Laboratory, Bar Harbor, Maine.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|June 25, 2014
PubMed
Summary

The Gene Expression Database for Mouse Development (GXD) integrates complex gene expression data to advance developmental research. This comprehensive resource aids scientists in understanding mouse development through accessible, curated data and powerful search tools.

Keywords:
anatomy ontologydata integrationimmunohistochemistryin situ hybridizationliterature curationonline resource

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Area of Science:

  • Developmental Biology
  • Bioinformatics
  • Genomics

Background:

  • Understanding complex molecular mechanisms in development requires integrating diverse research data.
  • The Gene Expression Database for Mouse Development (GXD) was established to address this need by consolidating expression data.

Purpose of the Study:

  • To illustrate the progress in integrating developmental data using GXD as a case study.
  • To discuss general issues relevant to developmental databases and research.

Main Methods:

  • GXD integrates multiple types of gene expression data (RNA in situ hybridization, immunohistochemistry, PCR, Northern/Western blots) from wild-type and mutant mice.
  • Data are curated from publications and electronic submissions, focusing on endogenous gene expression.
  • The database employs advanced search utilities for data retrieval.

Main Results:

  • Since 1998, GXD has grown significantly, now containing over 1.4 million annotated expression results and over 260,000 images.
  • Data and images are freely and widely available, accessible through various search functions.
  • The database supports research on mouse development by providing a rich repository of expression information.

Conclusions:

  • GXD serves as a vital resource for the scientific community, facilitating the study of developmental processes.
  • Effective utilization of GXD requires understanding its data acquisition, curation, and integration processes.
  • Community involvement in data submission is crucial for the continued growth and utility of GXD.