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Theophylline disposition in patients with COLD with and without hypoxemia
P du Souich1, B Hoen, C Saunier
1INSERM U. 14, Vandoeuvre-lès-Nancy, France.
Chest
|May 1, 1989
Abstract:
This study aimed to assess the effect of hypoxemia on theophylline disposition. Ten patients with a mean (+/- SEM) of 58 +/- 3 years with COLD (PaO2 55 +/- 1 mm Hg, PaCO2 46 +/- 2 mm Hg, and pH of 7.39 +/- 0.01) were hospitalized to have oxygen therapy. Before starting O2, they received intravenously, 4 mg/kg of theophylline over a 20-minute period; blood samples and urine were collected for six hours. The results suggested that hypoxia does not influence the disposition of theophylline or its metabolites.