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Positive and negative feedback learning and associated dopamine and serotonin transporter binding after
Alexandra Stolyarova1, Steve J O'Dell2, John F Marshall2
1University of California, Los Angeles, CA 90095, USA.
Behavioural Brain Research
|June 25, 2014
Summary
Methamphetamine exposure alters feedback learning, increasing reliance on positive rewards. Behavioral rigidity after methamphetamine treatment is linked to serotonin transporter binding.
Area of Science:
- Neuroscience
- Behavioral Science
- Pharmacology
Background:
- Performance monitoring involves learning from feedback and adjusting behavior.
- Dopamine (DA) and serotonin (5HT) pathways are crucial for reward learning.
- Psychostimulant-induced cognitive deficits may stem from altered feedback learning modulated by DA and 5HT.
Purpose of the Study:
- To investigate long-term effects of methamphetamine (mAMPH) on feedback learning and transporter binding.
- To analyze changes in positive and negative feedback learning after single vs. escalating mAMPH doses.
- To correlate behavioral rigidity and feedback sensitivity with striatal DA transporter (DAT) and frontocortical 5HT transporter (SERT) binding.
Main Methods:
- Rats pretreated with single or escalating doses of mAMPH underwent reversal learning tasks.
- Trial-by-trial analysis assessed sensitivity to positive and negative feedback.
- Striatal DAT and frontocortical SERT binding were measured post-treatment.
Main Results:
- mAMPH-pretreated rats showed increased sensitivity to and reliance on positive feedback.
- No significant alteration in overall negative feedback sensitivity was observed.
- Behavioral rigidity (consecutive errors) was negatively correlated with frontocortical SERT binding.
- Positive feedback sensitivity was negatively correlated with striatal DAT binding.
Conclusions:
- Methamphetamine exposure induces lasting changes in feedback learning, particularly enhancing positive feedback reliance.
- Serotonin and dopamine systems play distinct yet overlapping roles in overcoming behavioral rigidity and adapting to new reward contingencies.
- Findings highlight the neurobiological underpinnings of psychostimulant-induced cognitive impairments in reward-based learning.
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