In vivo implantation of hydrophobic acrylic intraocular lenses with surface modification

To assess the surface properties of modified hydrophobic acrylic intraocular lenses (IOL) implanted in rabbits.

The hydrophobic acrylic IOLs were modified with monomer vinyl pyrrolidone by surface modification technique. Phacoemulsification combined with IOL implantation was conducted in 9 rabbits (18 eyes). Postoperative responses were observed by slit-lamp microscope at 3, 7, 15, 30, 90 days after surgery.

During the early stage after IOL implantation, corneal edema and anterior chamber fibrin exudation were observed. The exudate fluid was almost absorbed at the 15th day postoperatively. At 7th day, the anterior chamber exudation in the modification group was significantly less severe than that in non-modification group (P < 0.05). Posterior capsular opacification occurred at 30th day after surgery and was aggravated 90 days later. IOL dislocation was seen in 5 eyes and occlusion of pupil in 3 eyes.

The hydrophobic acrylic IOLs with surface modification have improved surface properties and higher uveal biocompatibility.