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Donor-Acceptor Bridging via Twisted Quasi-Double-Bond: A Facile Design Strategy for Typical NIR-II AIEgen with
Chunbin Li1,2, Jen-Shyang Ni3, Pengfei Zhang1,4
1Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, State Key Laboratory of Nervous System Disorder, Division of Life Science, and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China.
Abstract:
A facile design strategy for NIR-II fluorophores with aggregation-induced emission (AIE) characteristics was presented. This kind of NIR-II AIE luminogen, TSPCI is an example, is by the strong acceptor-donor bridging via a twisted quasi-double-bond (TQDB). Theoretical calculations revealed that the introduction of TQDB was the major factor for quenching of the photoexcited TSPCI molecule in the solution state. TSPCI showed excellent NIR-II imaging performance for in vivo dynamic imaging with high contrast and penetration depth. TSPCI holds great potential as a building block to easily fabricate activatable fluorescent probes with superior responsive ability in the second NIR optical window for in vivo imaging applications.
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