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Updated: Apr 27, 2026
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Trifluoromethylation of alkenes with concomitant introduction of additional functional groups
Hiromichi Egami1, Mikiko Sodeoka
1Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); Sodeoka Live Cell Chemistry Project, ERATO, JST, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan).
Abstract:
The trifluoromethyl group is found in many synthetic bioactive compounds, and the difunctionalization of a C=C bond, as a powerful strategy for the construction of compounds with various functional groups, has been intensively investigated. Therefore, the difunctionalizing trifluoromethylation of alkenes has attracted growing interest because of the potential of the products as building blocks for bioactive molecules. In this review, we focus on recent advances in the trifluoromethylation of alkenes with concomitant introduction of additional functional groups.
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