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Updated: Apr 27, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
Published on: October 17, 2015
Amyloid precursor protein and neural development
Maya Nicolas1, Bassem A Hassan2
1VIB Center for the Biology of Disease, VIB, 3000 Leuven, Belgium Center for Human Genetics, University of Leuven School of Medicine, 3000 Leuven, Belgium Doctoral Program in Molecular and Developmental Genetics, University of Leuven Group Biomedicine, 3000 Leuven, Belgium.
Abstract:
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.
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