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The coagulation system in melioidosis: from pathogenesis to new treatment strategies

Liesbeth Martine Kager1, Tom van der Poll, Willem Joost Wiersinga

  • 1Academic Medical Center, Center for Experimental and Molecular Medicine (CEMM), University of Amsterdam, Meibergdreef 9, Room G2-130,1105 AZ, Amsterdam, The Netherlands.

Expert Review of Anti-Infective Therapy
|June 26, 2014
PubMed

Insights

Melioidosis, a severe bacterial infection, involves complex interactions with the body's clotting system. Understanding coagulation, anticoagulation, and fibrinolysis is crucial for managing this disease and improving patient outcomes.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Immunology

Background:

  • Melioidosis is a serious infection caused by Burkholderia pseudomallei, prevalent in Southeast Asia and Northern Australia.
  • It can lead to severe sepsis, multi-organ failure, and high mortality rates, even with antibiotic treatment.

Purpose of the Study:

  • To review recent research on the role of the coagulation system in melioidosis.
  • To explore the interplay between coagulation, anticoagulation, fibrinolysis, and inflammation in patients and experimental models.

Main Methods:

  • Review of recent studies investigating coagulation pathways in melioidosis.
  • Analysis of data from both human patients and experimental settings.

Main Results:

  • Melioidosis involves a pro-inflammatory response and significant alterations in the coagulation system.
  • A procoagulant state, reduced anticoagulant activity, and activated fibrinolysis are observed.
  • These hemostatic changes are closely linked to inflammatory markers.

Conclusions:

  • The coagulation system plays a significant, potentially host-protective role in melioidosis.
  • Further investigation into these complex hemostatic and inflammatory interactions is warranted for therapeutic development.
Keywords:
Burkholderia pseudomalleicoagulationfibrinolysisinflammationmelioidosispneumoniaprotein C systemsepsis

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