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Updated: Apr 27, 2026

Monitoring Acupuncture Effects on Human Brain by fMRI
Published on: April 8, 2010
Correlation between the Effects of Acupuncture at Taichong (LR3) and Functional Brain Areas: A Resting-State
Chunxiao Wu1, Shanshan Qu1, Jiping Zhang1
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong Province 510515, China.
Abstract:
Functional magnetic resonance imaging (fMRI) has been shown to detect the specificity of acupuncture points, as proved by numerous studies. In this study, resting-state fMRI was used to observe brain areas activated by acupuncture at the Taichong (LR3) acupoint. A total of 15 healthy subjects received brain resting-state fMRI before acupuncture and after sham and true acupuncture, respectively, at LR3. Image data processing was performed using Data Processing Assistant for Resting-State fMRI and REST software. The combination of amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) was used to analyze the changes in brain function during sham and true acupuncture. Acupuncture at LR3 can specifically activate or deactivate brain areas related to vision, movement, sensation, emotion, and analgesia. The specific alterations in the anterior cingulate gyrus, thalamus, and cerebellar posterior lobe have a crucial effect and provide a valuable reference. Sham acupuncture has a certain effect on psychological processes and does not affect brain areas related to function.

