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Detection of Hodgkin Transformation in a Case of Chronic Lymphocytic Leukemia by PET/CT
Sabire Yılmaz1, Meftune Ozhan1, Sertaç Asa1
1Istanbul University Cerrahpasa Faculty of Medicine, Department of Nuclear Medicine, İstanbul, Turkey.
Abstract:
Richter's transformation (RT) represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). CLL/SLL may convert also to Hodgkin's lymphoma, the so-called Hodgkin's variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients with RT generally have a poor prognosis, with prompt recognition optimise clinical management. Whole-body PET scan with 18F-FDG can be used for detection of RT of CLL/SLL. We describe the case of 64-year-old woman with CLL/SLL who developed Hodgkin lymphoma detected with PET/CT.
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