Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

388
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
388
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

597
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
597
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.3K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.3K
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

168
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
168
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

5.4K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.4K
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

342
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
342

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A straightforward method for assessing the technical image quality of reconstructed and synthetic 2D images for Digital breast tomosynthesis systems.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Typical values of z-resolution for different Digital Breast Tomosynthesis systems evaluated in a multicenter study.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2024
Same author

Severe chronic rhinosinusitis treated with dupilumab, a real-life analysis of early effectiveness.

European review for medical and pharmacological sciences·2023
Same author

Workload Balancing in Emergency Night Shifts for a Multicenter Diagnostic Imaging Department: a RIS-Integrated Solution.

Journal of digital imaging·2023
Same author

Autotransplantation with tooth replica: Technical note.

Journal of stomatology, oral and maxillofacial surgery·2022
Same author

High-precision measurement of the <i>W</i> boson mass with the CDF II detector.

Science (New York, N.Y.)·2022
Same journal

Bayesian Convolutional Neural Networks in Medical Imaging Classification: A Promising Solution for Deep Learning Limits in Data Scarcity Scenarios.

Journal of digital imaging·2023
Same journal

Detecting and Characterizing Inferior Vena Cava Filters on Abdominal Computed Tomography with Data-Driven Computational Frameworks.

Journal of digital imaging·2023
Same journal

DMCA-GAN: Dual Multilevel Constrained Attention GAN for MRI-Based Hippocampus Segmentation.

Journal of digital imaging·2023
Same journal

Left Ventricular Myocardial Dysfunction Evaluation in Thalassemia Patients Using Echocardiographic Radiomic Features and Machine Learning Algorithms.

Journal of digital imaging·2023
Same journal

Public Imaging Datasets of Gastrointestinal Endoscopy for Artificial Intelligence: a Review.

Journal of digital imaging·2023
Same journal

External Validation of Robust Radiomic Signature to Predict 2-Year Overall Survival in Non-Small-Cell Lung Cancer.

Journal of digital imaging·2023
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

1.8K

Patient dose management solution directly integrated in the RIS: "Gray Detector" software.

A Nitrosi1, A Corazza, M Bertolini

  • 1Medical Physics Unit, Arcispedale Santa Maria Nuova Hospital IRCCS, Reggio Emilia, Italy, nitrosi.andrea@asmn.re.it.

Journal of Digital Imaging
|June 27, 2014
PubMed
Summary
This summary is machine-generated.

A new software, "Gray Detector," links patient radiation dose information from X-ray imaging to patient records. This improves data accuracy and supports patient-centered clinical decisions by optimizing the image quality-to-dose ratio.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.2K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

19.7K

Related Experiment Videos

Last Updated: Apr 27, 2026

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies
07:12

Real-Time Monitoring of Neurocritical Patients with Diffuse Optical Spectroscopies

Published on: November 19, 2020

1.8K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.2K
Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

19.7K

Area of Science:

  • Medical Physics
  • Radiology Informatics

Background:

  • Patient radiation dose information from X-ray imaging is often fragmented across image headers, PACS, and Modality Performed Procedure Step messages.
  • Linking this dosimetric data to patient records within the Radiological Information System (RIS) is crucial for accurate analysis and clinical decision-making.

Purpose of the Study:

  • To develop and implement a software solution for effectively extracting and integrating patient radiation dose information into the RIS.
  • To enable vendor-neutral integration of dosimetric data from various X-ray modalities.
  • To facilitate accurate association of dose information with specific patient exams, especially in complex cases like multi-segment CT scans.

Main Methods:

  • Development of the "Gray Detector" software utilizing complementary extraction methods.
  • Querying image headers and analyzing Modality Performed Procedure Step messages, individually or in combination.
  • Linking extracted dosimetric information to patient records and unique report codes within the RIS to manage multiple protocols and ensure accurate association.

Main Results:

  • The
  • Gray Detector
  • software successfully integrates dosimetric information from diverse X-ray modalities in a vendor-neutral manner.
  • Linking dose data to RIS records and report codes resolved issues with associating dose values in multi-segment exams.
  • Analyses revealed dependencies of dosimetric indexes on modality type, patient age, and healthcare professionals involved.

Conclusions:

  • Integrating patient radiation dose data into the RIS provides essential context for analysis.
  • This approach optimizes the image quality-to-dose ratio, enabling more informed, patient-centered clinical decisions.
  • The developed software facilitates accurate and comprehensive radiation dose management in diagnostic imaging.