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Steroid-responsive idiopathic cold agglutinin disease: a case report
M Lahav1, I Rosenberg, A J Wysenbeek
1Department of Internal Medicine, Beilinson Medical Center, Petah Tiqva, Israel.
Acta Haematologica
|January 1, 1989
Summary
Idiopathic cold agglutinin disease (ICAD) can respond to corticosteroid therapy, especially when autoantibodies are low titer and have a wide thermal range. This suggests a potential treatment avenue for specific ICAD cases.
Area of Science:
- Hematology
- Immunology
Background:
- Idiopathic cold agglutinin disease (ICAD) is a rare autoimmune hemolytic anemia.
- Patients typically do not respond to corticosteroid therapy.
Observation:
- A case of ICAD presented with low titer (1:32) cold agglutinins.
- These autoantibodies exhibited a wide thermal range (4-37°C).
Findings:
- The patient's ICAD responded favorably to corticosteroid treatment.
- Previously reported similar cases also showed responsiveness to corticosteroids.
Implications:
- Specific characteristics of cold agglutinins may predict corticosteroid responsiveness in ICAD.
- A trial of corticosteroid therapy is warranted for ICAD patients with these autoantibody features.