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Lupus anticoagulant and late onset seizures
1Department of Neurology, Tel-Aviv Medical Center, Tel-Aviv University, Israel.
Acta Neurologica Scandinavica
|February 1, 1989
Summary
Late-onset epileptic seizures may be linked to lupus anticoagulant, a blood clotting disorder. This finding suggests a potential link between hypercoagulability and unexplained seizures in adults.
Area of Science:
- Neurology
- Hematology
- Autoimmunity
Background:
- Late-onset epilepsy presents diagnostic challenges.
- Autoimmune disorders can affect neurological function.
- Lupus anticoagulant is associated with hypercoagulability.
Observation:
- Four patients with late-onset epileptic seizures tested positive for lupus anticoagulant.
- Three patients exhibited focal neurological signs or EEG abnormalities.
- Cerebral imaging revealed no significant pathology, except an old infarct in one patient.
Findings:
- A potential association between lupus anticoagulant and late-onset seizures was observed.
- Patients did not meet criteria for systemic lupus erythematosus.
- The presence of lupus anticoagulant may indicate an underlying hypercoagulable state.
Implications:
- This suggests seizures could be a unique manifestation of ischemic events due to hypercoagulability.
- Further research is needed to explore the causal relationship.
- Consider screening for lupus anticoagulant in adults with new-onset seizures.