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Related Experiment Video

Updated: Apr 27, 2026

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Hemispheric differences in the mesostriatal dopaminergic system.

Ilana Molochnikov1, Dana Cohen1

  • 1The Leslie and Susan Gonda Multidisciplinary Brain Research Center, Bar-Ilan University Ramat-Gan, Israel.

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|June 27, 2014
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Summary

This review finds evidence for experience-dependent dopamine (DA) imbalance in the brain, particularly in the nigrostriatal pathway. This imbalance is linked to animal behavior and may involve regulatory mechanisms.

Keywords:
VTAdopaminelateralitynucleus accumbensside preferencestriatum

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Area of Science:

  • Neuroscience
  • Neurochemistry

Background:

  • The mesostriatal dopaminergic system is crucial for motor and limbic functions.
  • Hemispheric differences in striatal dopamine (DA) levels, turnover, and receptor activity may influence these functions.

Purpose of the Study:

  • To review evidence for endogenous, inter-hemispheric DA imbalance.
  • To examine the relationship between DA imbalance and animal behavior.
  • To characterize laterality in the nigrostriatal and mesolimbic DA systems.

Main Methods:

  • Review of studies measuring DA and metabolite concentrations.
  • Analysis of evidence for endogenous DA imbalance.
  • Assessment of anatomical substrates for DA imbalance.
  • Examination of behavioral correlates of DA imbalance.
  • Characterization of inter-hemispheric laterality symmetry.

Main Results:

  • Supporting evidence for experience-dependent endogenous DA imbalance exists, regulated by compensatory mechanisms.
  • The link between DA imbalance and behavior is clearer in the nigrostriatal system than the mesolimbic system.
  • Nigrostriatal system shows symmetrical laterality; mesolimbic system shows asymmetrical laterality, indicating hemispheric specialization.

Conclusions:

  • Experience-dependent DA imbalance is supported by regulatory mechanisms.
  • Hemispheric specialization is evident in the mesolimbic system's asymmetrical laterality.
  • The potential for animal training to non-invasively treat DA imbalance is controversial but promising.