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Apraxia, pantomime and the parietal cortex.

E Niessen1, G R Fink2, P H Weiss2

  • 1Cognitive Neuroscience, Institute of Neuroscience & Medicine (INM-3), Research Centre Jülich, Jülich, Germany.

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|June 27, 2014
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Summary
This summary is machine-generated.

Apraxia, a motor cognition disorder, involves difficulty pantomiming object use after left hemisphere stroke. Both lesion and functional imaging studies reveal a left fronto-parietal network is crucial for this action, with the parietal cortex playing a key role.

Keywords:
Lesion mappingMotor cognitionStrokeToolsfMRI

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Area of Science:

  • Neuroscience
  • Cognitive Neurology
  • Neuroimaging

Background:

  • Apraxia is a common higher motor cognition disorder following left hemispheric stroke.
  • Deficits in pantomiming object use are a primary symptom of apraxia.
  • The precise neural underpinnings of pantomiming remain debated.

Purpose of the Study:

  • To systematically review and meta-analyze structural and functional neuroimaging studies on the neural basis of pantomiming object use.
  • To clarify the role of specific brain regions in apraxia, particularly the left parietal cortex.

Main Methods:

  • Systematic literature search identifying 10 structural and 12 functional imaging studies (fMRI/PET).
  • Meta-analysis of lesion data and functional activation patterns associated with pantomiming deficits and performance.
  • Comparison of findings from structural lesion studies versus functional imaging studies.

Main Results:

  • Structural lesion studies implicate left frontal, parietal, and temporal regions in pantomiming deficits.
  • Functional imaging studies consistently show left parietal activation during pantomiming, often with frontal or temporal involvement.
  • Stringent fMRI studies highlight the left parietal cortex's role in both storing and activating motor schemas for pantomime.

Conclusions:

  • A left-hemispheric fronto-(temporal)-parietal network underlies pantomiming object use, supported by both lesion and functional data.
  • The left parietal cortex is critically involved in pantomime execution, including schema activation.
  • Age-related differences between study populations may influence observed neural representations of pantomiming.